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In vitro metabolism of the phosphorothioate radioprotectors WR-2721 and WR-3689

✍ Scribed by John C. Livesey; Janet S. Rasey; Sarah Vertrees; Lynne M. Freeman; Sara Magee; Norma J. Nelson; Lay Chin; Zdenka Grunbaum; Kenneth A. Krohn


Book ID
118385491
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
155 KB
Volume
39
Category
Article
ISSN
0163-7258

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Three 4-chlorophenyl diaminoalkylthiophasphate esters of WR -2721, WR-3689 and WR-151327 were synthesized and evaluated for in vitro cytotoxicity and in vitro and in vivo radioprotective efficacy against Chinese hamster V-79 cells and CD2F1 male mice, respectively.