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In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human

โœ Scribed by W. N. Wu; L. A. McKown; E. E. Codd; R. B. Raffa

Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
592 KB
Volume
27
Category
Article
ISSN
0378-7966

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Fenobam [(Fn); N-(3-chlorophenyl)-N-(4,5-dihydro-l -methyl-4-0x0-1 Kimidazole-2-yl)urea] sulfate is a novel agent with potent anxiolytic activity in rats. [14C]Fn sulfate was administered as an oral solution (250 mglkg) to male Wistar rats, and 52% of the administered dose was excreted in urine (0-5