In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human
β Scribed by Alan L. Mendrala; Patrick W. Langvardt; Kenneth D. Nitschke; John F. Quast; Richard J. Nolan
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 1007 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0340-5761
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Experiments were performed to evaluate reproductive and developmental toxicology in rats and rabbits exposed to styrene oxide by inhalation. Female rats were exposed to 100 or 300 ppm styrene oxide or to filtered air for 7 h/day, 5 daydweek for 3 weeks. Extensive mortality occurred in rats that rece
## Styrene is one of the most important monomers produced worldwide. IARC classified styrene as a possible carcinogen to humans (group 2B). Styrene-7,8-oxide (SO) is the main reactive metabolite of styrene, and it is found to be genotoxic in several in vitro test systems. Styrene and styrene-7,8-