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In vitro metabolism of S-(+)- and R-(−)-enantiomers of mirtazapine

✍ Scribed by L.P.C. Delbressine; R.H.M. Gloudemans; C.H.J. Verhoeven; R.M.E. Vos; R.M. Pinder; N.V Organon


Book ID
118600569
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
186 KB
Volume
8
Category
Article
ISSN
0924-977X

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The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma