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In Vitro Metabolism of Chloroprene: Species Differences, Epoxide Stereochemistry and a De-chlorination Pathway

โœ Scribed by Cottrell, Lisa; Golding, Bernard T.; Munter, Tony; Watson, William P.

Book ID
126875624
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
122 KB
Volume
14
Category
Article
ISSN
0893-228X

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Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying