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Species differences in the in vitro metabolism of HEOM a chlorinated cyclodiene epoxide

โœ Scribed by G.A. El Zorgani; C.H. Walker; K.A. Hassall


Book ID
118935141
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
208 KB
Volume
9
Category
Article
ISSN
0024-3205

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Species differences in in vitro and in v
โœ Hiroshi Komura; Masahiro Iwaki ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 272 KB ๐Ÿ‘ 1 views

Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying