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In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adélie penguins

✍ Scribed by Sompon Wanwimolruk; Hu Zhang; Peter F Coville; Dorothy J Saville; Lloyd S Davis

Book ID
117567706
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
131 KB
Volume
124
Category
Article
ISSN
0742-8413

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In vitro hepatic metabolism of CYP3A-med
In vitro hepatic metabolism of CYP3A-mediated drugs quinine and midazolam in the common brush-tailed possum (Trichosurus vulpecula)
✍ Ping-Chuen Ho; Xiao-Xing Luo; Jackie S. Macauley; Murray R. Grigor; Sompon Wanwi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB

## Abstract This report characterizes the P450 isoenzymes involved in quinine metabolism in liver microsomes of the common brush‐tailed possum (__Trichosurus vulpecula__). The mean maximal velocity (__V__~max~) for 3‐hydroxyquinine formation in possum livers was 1,512 ± 510 pmol/mg protein/min (mal