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CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes

โœ Scribed by Xiao-ping ZHAO; Jiao ZHONG; Xiao-quan LIU; Guang-ji WANG


Book ID
111355121
Publisher
Nature Publishing Group
Year
2007
Tongue
Chinese
Weight
633 KB
Volume
28
Category
Article
ISSN
1671-4083

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Both indinavir and troleandomycin (CYP3A inhibitors) are incapable of completely inhibiting dextromethorphan metabolism to 3-methoxymorphinan in human liver microsomes. It is hypothesized that CYPs in addition to CYP3A4 and 3A5 contribute to this biotransformation. The effect of CYP-selective inhibi