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In vitro expansion of antigen-specific CD8+ T cells distorts the T-cell repertoire

✍ Scribed by Koning, Dan; Costa, Ana I.; Hasrat, Raiza; Grady, Bart P.X.; Spijkers, Sanne; Nanlohy, Nening; Keşmir, Can; van Baarle, Debbie

Book ID
121775066
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
297 KB
Volume
405
Category
Article
ISSN
0022-1759

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## Abstract Foxp3^+^ Treg are crucial for the maintenance of self‐tolerance and have been shown to control CD8^+^ T‐cell effector functions. In addition, Treg are thought to control the priming of CD8^+^ T cells, which recognize the same antigens as Treg. Taking advantage of our model of peripheral