Reduced folates have been shown to increase the cytotoxicity of 5-fluorouracil (FUra) by stabilizing the fluorodeoxyuridine monophosphate:thymidylate synthase complex, thus increasing the block in the DNA synthetic pathway. Using an in vitro tetrazolium colorimetric ( M T Q cytotoxic assay, we teste
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines
β Scribed by Yoshikazu Sugimoto; Yuichiro Ohe; Kazuto Nishio; Tohru Ohmori; Yasuhiro Fujiwara; Nagahiro SAijo
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 755 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0344-5704
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