In vitro dissolution and in vivo absorption of nitrofurantoin from deoxycholic acid coprecipitates
โ Scribed by Roger G. Stoll; Theodore R. Bates; James Swarbrick
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 521 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A major goal of the pharmaceutical scientist is "nding a relationship between an in vitro characteristic of an oral dosage form and its in vivo performance. One such relationship between drug dissolution (or absorption) in vivo and that in vitro is known as an &in vitro}in vivo correlation' (IVIVC)
Four 50 mg and three 100 mg marketed nitrofurantoin tablets were studied in 14 healthy male subjects. Urine was collected 1, 2, 3, 4, 6, 8, 12, and 23 h after each dose, and nitrofurantoin was assayed by HPLC. The in vitro dissolution of the tablets was determined using USP Apparatus 1 and 2, with 0