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In Vitro dehalogenation of para-substituted aromatic halides in rat liver preparations

✍ Scribed by M. T. Scott; J. E. Sinsheimer

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 531 KB
Volume: 73
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600730819

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✦ Synopsis

The in vitro dehalogenation of a series of para-substituted halobenzenes was studied using HPLC separation followed by scintillation counting or neutron-activation analysis. Microsomal and cytosolic deiodination were established for iodobenzene substrates whose para-substituents were CO2H, CHO, NO2, OH, and C6H5 but not for para-iodobenzonitrile. A nonglutathione cytosolic deiodinase was only indicated with 4-iodobiphenyl as the substrate. In vitro dehalogenation could not be established for 4-bromobiphenyl using neutron-activation analysis.

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