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In vitro cytotoxicity and in vivo tumor enhancement induced by mouse spleen cells autosensitized in vitro

✍ Scribed by David Ilfeld; Claude Carnaud; Irun R. Cohen; Nathan Trainin

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
748 KB
Volume
12
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The immuno‐reactivity of C57BL mouse spleen cells previously sensitized in vitro against syngeneic fibroblasts or syngeneic 3LL Lewis tumor cells was investigated. The sensitized spleen cells were assayed in vitro to test their cytotoxicity against the 3LL tumor cells. In addition, spleen cells autosensitized against syngeneic fibroblasts were mixed with 3LL tumor cells and injected into syngeneic recipient mice in order to ascertain their influence on tumor growth. The in vitro assay indicated that lymphoid cells specifically sensitized against either fibroblasts or tumor cells were equally cytotoxic against the 3LL target cells. On the other hand, in the in vivo experiments lymphoid cells sensitized against syngeneic fibroblasts promoted the growth of the 3LL tumor. An attempt to explain the underlying mechanisms involved in the paradoxical behavior of autosensitized lymphocytes is reported herein.

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