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In vitro cisplatin effects on phagocyte functions

✍ Scribed by Ruggiero Fumarulo; Silvana Riccardi; Romeo Pantaleo; Mauro Coluccia; Domenico Giordano; Michele Aresta

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
411 KB
Volume
35
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effects of cis‐diamminedichloroplatinum (11) (cisplatin), a drug used in cancer chemotherapy, on the oxidative metabolism, endocytosis, chemotaxis and exocytosis of guinea‐pig polymorphonuclear leukocytes were studied. All these functions were negatively influenced, but the same effect (50% inhibition) was observed at different drug concentrations (3 × 10^−5^ M for chemotaxis, 10^−4^ M for O~2~ consumption by FMLP and β‐glucuronidase release, 10^−3^ M for O~2~ consumption by PMA and for zymosan engulfment). The effects of the drug can be explained by its ability to bind to membrane proteins, essentially to ‐SH groups.

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