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The long-term effect of cisplatin on renal function

✍ Scribed by Paul Fjeldborg; Jesper Sørensen; Poul E. Helkær

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
367 KB
Volume
58
Category
Article
ISSN
0008-543X

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✦ Synopsis

The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diuresis above 100 ml/hour. GFR (glomerular filtralrion rate: "Cr-EDTA clearance) fell by 12.5% (median, P < 0.01) compared with the pretreatment level. Effective renal plasma flow ('251-hippuran clearance) was estimated to be likewise reduced. The serum creatinine level rose 8 pmol/l (median, P < 0.05) during the treatment period with no further rise afterwards. Serum magnesium and urinary excretion of beta-2-microglobulin were normal. The results indicate is moderate and permanent reduction in GFR with no signs of long-term tubular defects in patients treated with cisplatin.

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