✦ LIBER ✦

In vitro cartilage degradation by escherichia coli and staphylococcus aureus

✍ Scribed by R. Lane Smith; Thomas C. Merchant; David J. Schurman

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 553 KB
Volume: 25
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780250413

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Effects of Escherichia coli and Staphylococcus aureus on cartilage and chondrocytes in culture are reported. Under these conditions, bacterial effects on cartilage degradation and cell viability are measured in the absence of inflammation. E coli causes a 28% loss and S aureus an 83% loss of cartilage glycosaminoglycan within 48 hours. Collagen content is unchanged. Both bacterial species induce chondrocyte death in explants and in monolayers within 48 hours. Bacterial effects on glycosaminoglycans and cell viability do not result from depletion of nutrients from the culture medium. Serum in the culture media inhibits the bacterial effects on cartilage degradation but does not prevent cell death.

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