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In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane

✍ Scribed by Chingju W. Sheu; Frances M. Moreland; Jung Keun Lee; Virginia C. Dunkel

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 411 KB
Volume: 11
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.2850110106

No coin nor oath required. For personal study only.

✦ Synopsis

The spermicidal surfactant nonoxynol-9 (Igepal CO-630, GAF Corp.) and a potential impurity, lP-dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol-9, tested at levels up to 10 pglml, did not induce transformation, whereas dioxane was very active in the induction of type III foci in the cultured BALBl3T3 cells.

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