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In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin

✍ Scribed by Thomas G. Hammond; Sophie L. Regan; Xiaoli Meng; James L. Maggs; Rosalind E. Jenkins; J. Gerry Kenna; Jean G. Sathish; Dominic P. Williams; B. Kevin Park

Book ID
113934078
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
97 KB
Volume
290
Category
Article
ISSN
0300-483X

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Furosemide 1-O-acyl glucuronide (Fgnd) was reversibly bound to a single class of binding sites on human serum albumin (HSA), and the binding of Fgnd decreased with increasing F concentrations, suggesting that Fgnd binds to the same warfarin binding sites on HSA as F binds. The rate of Fgnd degradati