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In vitro antitumor activity of N-glycosyl sulfonamides

✍ Scribed by Rosana Crespo; Margarita G. de Bravo; Pedro A. Colinas; Rodolfo D. Bravo

Book ID
104004899
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
171 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

A series of a-D-hex-2-enopyranosyl sulfonamides was evaluated for their antiproliferative activity against human hepatocellular liver carcinoma (HepG2) and human lung adenocarcinoma (A549) cell lines. The most potent compound (2,4,6-tri-O-acetyl-3-deoxy-a-D-erythro-hex-2-enopyranosyl ethanesulfonamide) showed antiproliferative properties in the micromolar range. The SARs of these sulfonamidoglycoside which includes the influence of carbohydrate rings and sulfonamide class are described.

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