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In vitro and in vivo inhibition of glycolytic enzymes by acrylamide

✍ Scribed by Mohammad I. Sabri

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
728 KB
Volume
1
Category
Article
ISSN
1044-7393

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The effects of acrylamide and eight analogues on mouse brain glycolytic enzymes were studied in vitro. Most of the neurotoxic and non-neurotoxic analogues showed inhibitory effects on enolases. Their inhibitory constants, I50, for both mouse brain total enolases and purified bovine neuron specific e

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The effect of acrylamide and six analogues on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and enolase in sciatic nerve was examined in rats after their prolonged administration in drinking water. After 15 days' treatment with acrylamide and N-isopropylacrylamide, slight signs of peripheral neur