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In vitro and in vivo immunosuppressive activity of a novel anthracycline, 13-deoxy, 5-iminodoxorubicin

✍ Scribed by Richard D. Olson; Mark B. Headley; Alma Hodzic; Gerald M. Walsh; Denise G. Wingett

Book ID: 116576130
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 447 KB
Volume: 7
Category: Article
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2007.01.010

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## Abstract The new amphiphilic dinucleoside phosphate, 2′‐deoxy‐5‐fluorouridylyl‐(3′→5′)‐2′‐deoxy‐5‐fluoro‐__N__^4^‐octadecylcytidine (4) was synthesized on a gram scale, using the phosphotriester method, starting from the cytostatic drug 2′‐deoxy‐5‐fluorouridine (5FdU) and 2′‐deoxy‐5‐fluoro‐__N__