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In vitro and in vivo effects of leflunomide, Brequinar, and cyclosporine on pyrimidine biosynthesis

✍ Scribed by H.T. Silva Jr.; R.A. Shorthouse; M. Löffler; R.E. Morris; W. Cao

Book ID: 117234485
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 185 KB
Volume: 29
Category: Article
ISSN: 0041-1345
DOI: 10.1016/s0041-1345(96)00523-4

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## Abstract The aim of this study was to compare the effect of cyclosporin A (CsA) in inbred Lewis rats with published assessment of immunotoxicity in ‘classical’ outbred Wistar rats. A second purpose was to consider the contribution of a panel of __in vitro__ assays in cell cultures when added to