Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo
✍ Scribed by Andersson, Y; Engebraaten, O; Fodstad, Ø
- Book ID
- 110000177
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 489 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0007-0920
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## Abstract The aim of this study was to compare the effect of cyclosporin A (CsA) in inbred Lewis rats with published assessment of immunotoxicity in ‘classical’ outbred Wistar rats. A second purpose was to consider the contribution of a panel of __in vitro__ assays in cell cultures when added to
A Ber-H2/saporin immunotoxin, consisting of the single-chain ribosome-inactivating protein saporin-S6 and the anti-CD30 monoclonal antibody Ber-H2, gave encouraging results in the treatment of refractory Hodgkin's disease but caused a transient hepatotoxicity. The accumulation of Ber-H2/saporin conj