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In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

✍ Scribed by Olivia M. Merkel; Rudolf Urbanics; Peter Bedőcs; Zoltán Rozsnyay; László Rosivall; Miklós Toth; Thomas Kissel; Janos Szebeni


Book ID
108070162
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
808 KB
Volume
32
Category
Article
ISSN
0142-9612

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## Abstract ## Background Polyethylenimine (PEI) is toxic although it is one of the most successful and widely used gene delivery polymers with the aid of the proton sponge effect. Therefore, development of new novel gene delivery carriers having high efficiency with less toxicity is necessary. #