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In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor

✍ Scribed by Brigitte Arends; Bart Spee; Gaby Hoffmann; Georgina E.G. Jansen; Estel Slump; Edoardo Auriemma; Jooske IJzer; Wieger Hemrika; Roland A. Romijn; Karin H.A. van der Heijden-Liefkens; Paul J.A. Sondermeijer; Ted S.G.A.M. van den Ingh; Louis C. Penning; Jan Rothuizen


Book ID
113939244
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
708 KB
Volume
178
Category
Article
ISSN
1090-0233

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Keratinocyte growth factor (KGF) promotes epithelial growth and differentiation and has potent effects on the liver. The coinjection of lipopolysaccharide (LPS) and D-galactosamine (GalN) results in hepatic failure in mice. Mechanistically, LPS-induced tumor necrosis factor (TNF) triggers hepatocyte