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In vitro and in vivo anticancer activity of mitozolomide and sparsomycin in human tumor xenografts, murine tumors and human bone marrow

✍ Scribed by Heinz H. Fiebig; Dietmar P. Berger; Karin Köpping; Harry C. J. Ottenheijm; Zbigniew Zylicz

Book ID
112580939
Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
727 KB
Volume
116
Category
Article
ISSN
1432-1335

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In vivoantitumor activity of sparsomycin
In vivoantitumor activity of sparsomycin and its analogues in eight murine tumor models
✍ Zbigniew Zylicz; D. J. Theo Wagener; Helga Rennes; Eppo Kleijn; Peter Lelieveld; 📂 Article 📅 1988 🏛 Springer US 🌐 English ⚖ 507 KB

Sparsomycin (Sm) is a known inhibitor of ribosomal protein synthesis with an attractive anticancer potential. Recently, several analogues of Sm which are more active than the parent drug were selected for further study on the basis of in vitro investigations. Six analogues as well as the parent drug