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Triparanol suppresses human tumor growth in vitro and in vivo

โœ Scribed by Xinyu Bi; Xingpeng Han; Fang Zhang; Miao He; Yi Zhang; Xiu-Yi Zhi; Hong Zhao

Book ID
116303822
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
521 KB
Volume
425
Category
Article
ISSN
0006-291X

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## Abstract We have recently described MAZ51, an indolinone that blocks the ligandโ€induced autophosphorylation of VEGFRโ€3, a receptor tyrosine kinase that plays a central role in the regulation of lymphangiogenesis. Here we show that MAZ51 is able to block the proliferation of VEGFRโ€3โ€expressing hu