‘In vitro’ action of histamine and cimetidine on amylase secretion in the rat pancreas

✍ Scribed by Luis Jiménez Murillo; Julián Torre-Cisneros; Dr. Angeles Blanco-Molina; José López-Miranda; Rafael Angel Fernández de la Puebla; Francisco Pérez-Jiménez

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 249 KB
• Volume: 13
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510130508

✦ Synopsis

We report here the effect of histamine on amylase secretion in isolated lobules from the rat pancreas. Different concentrations of histamine increased amylase secretion, while the stimulatory effect was reduced by cimetidine although not by chlorpheniramine. These findings suggest that pancreatic lobules have H, receptors. On the other hand, bethanechol induced a stimulatory effect on pancreatic lobules that was inhibited by cimetidine. Vibrio cholerae toxin stimulated amylase secretion, but this effect was not reduced by cimetidine. Cimetidine may thus block the stimulated amylase secretion interfering with the Caz+ messenger system.