In situ Gelation of Supramolecular Hydrogel for Anti-Tumor Drug Delivery

✍ Scribed by Bin He; Jing Zeng; Yu Nie; Li Ji; Rui Wang; Yuan Li; Yao Wu; Li Li; Gang Wang; Xianglin Luo; Zhirong Zhang; Zhongwei Gu

• Book ID: 102934345
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 653 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200900225

✦ Synopsis

Abstract

A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host‐guest interaction between α‐cyclodextrins (α‐CDs) and methylated poly(ethylene glycol) grafted poly(α,β‐malic acid) (mPEG‐g‐PMA). The hydrogel was characterized by ^1^NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of α‐CDs/mPEG‐g‐PMA acted as physical crosslink sites in the hydrogel. Anti‐tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti‐tumor effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery.

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