Rapidly in situ forming polyphosphoester-based hydrogels for injectable drug delivery carriers
β Scribed by He, Jinlin; Zhang, Mingzu; Ni, Peihong
- Book ID
- 120318328
- Publisher
- Royal Society of Chemistry
- Year
- 2012
- Tongue
- English
- Weight
- 777 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1744-683X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract This study sought to develop an injectable formulation for longβterm ocular delivery of fluocinolone acetonide (FA) by dissolving the antiβinflammatory drug and the biodegradable polymer poly(propylene fumarate) (PPF) in the biocompatible, waterβmiscible, organic solvent __N__βmethylβ2β
Aqueous solutions of blends of biodegradable triblock copolymers, composed of poly(DL-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity and formed a gel at body temperature. The gel window of the blend solutions coul