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In SilicoPrediction of Drug Permeability Across Buccal Mucosa

✍ Scribed by Amit Kokate; Xiaoling Li; Paul J. Williams; Parminder Singh; Bhaskara R. Jasti


Book ID
106493713
Publisher
Springer US
Year
2009
Tongue
English
Weight
259 KB
Volume
26
Category
Article
ISSN
0724-8741

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πŸ“œ SIMILAR VOLUMES


A novel flow through diffusion cell for
✍ Maria L.A.D. Lestari; Joseph A. Nicolazzo; Barrie C. Finnin πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 310 KB πŸ‘ 1 views

A novel flow through (FT) diffusion cell for assessing the permeability of compounds across the buccal mucosa was designed. Porcine buccal mucosa was mounted between two chambers with flow through capacity in both the donor and receptor chambers. The permeability of caffeine (CAF), triamcinolone ace

Effect of thermodynamic activities of th
✍ Amit Kokate; Xiaoling Li; Parminder Singh; Bhaskara R. Jasti πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 193 KB

The objective of this work was to delineate the contribution of thermodynamic activities of ionized and unionized species on buccal drug permeation. The flux and permeability of a model acidic (nimesulide) and basic (bupivacaine) drug were determined across porcine buccal mucosa at different pH cond

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Porcine buccal mucosa is frequently used for in vitro drug absorption studies as its structure and permeability characteristics are close to those of human tissue. However, this tissue model suffers from practical disadvantages, including a limited surface area, damage caused by mastication, and a f

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✍ Joseph A. Nicolazzo; Barry L. Reed; Barrie C. Finnin πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 267 KB

The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa was assessed using caffeine (CAF) and estradiol (E(2)) as model hydrophilic and lipophilic markers, respectively. The permeation of CAF and E(2) through porcine buccal mucosa was determined in modified