In Silico Approach to Identify Substrates and Inhibitors of Malaria Proteases
✍ Scribed by Boucher, Lauren E.; Lundqvist, Jenny; Hammond, Holly L.; Bosch, Jürgen
- Book ID
- 122200644
- Publisher
- Biophysical Society
- Year
- 2011
- Tongue
- English
- Weight
- 51 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0006-3495
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Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that proteolyze extracellular matrix components as well as a variety of functional proteins. Here we describe a bdegradomicsQ method that efficiently identifies substrates of MMP-14 in a complex protein mixture, such as