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From Poor Substrates to Good Inhibitors: Design of Inhibitors for Serine and Thiol Proteases †

✍ Scribed by Baggio, Ricky; Shi, Yi-Qun; Wu, Yong-qian; Abeles, Robert H.


Book ID
118189125
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
287 KB
Volume
35
Category
Article
ISSN
0006-2960

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Mechanism-based isocoumarin inhibitors f
✍ James C. Powers; Chih-Min Kam; Lakshmi Narasimhan; Joszef Oleksyszyn; Maria A. H 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

Isocoumarins are potent mechanism-based heterocyclic irreversible inhibitors for a variety of serine proteases. Most serine proteases are inhibited by the general serine protease inhibitor 3,4-dichloroisocoumarin, whereas isocoumarins containing hydrophobic 7-acylamino groups are potent inhibitors f