✦ LIBER ✦

Characterization of the Human Cytomegalovirus Protease As an Induced-Fit Serine Protease and the Implications to the Design of Mechanism-Based Inhibitors

✍ Scribed by LaPlante, Steven R.; Bonneau, Pierre R.; Aubry, Norman; Cameron, Dale R.; Déziel, Robert; Grand-Maître, Chantal; Plouffe, Céline; Tong, Liang; Kawai, Stephen H.

Book ID: 125940658
Publisher: American Chemical Society
Year: 1999
Tongue: English
Weight: 289 KB
Volume: 121
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja983904h

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Quinone Methides || Quinone Methides and

Quinone Methides || Quinone Methides and Aza-Quinone Methides as Latent Alkylating Species in the Design of Mechanism-Based Inhibitors of Serine Proteases andβ-Lactamases

✍ Rokita, Steven E. 📂 Article 📅 2009 🏛 John Wiley & Sons, Inc. 🌐 English ⚖ 487 KB

multidisciplinary Perspectives And Approaches To Quinone Methides Research the Wiley Series On Reactive Intermediates In Chemistry And Biology Investigates Reactive Intermediates From The Broadest Possible Range Of Disciplines. The Contributions In Each Volume Offer Readers Fresh Insights Into The

Comparison of inhibitor binding to felin

Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: Structure-based drug design and the resistance problem

✍ Ben M. Dunn; Michael W. Pennington; D. Constanza Frase; Kevin Nash 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 843 KB

The design and synthesis of compounds targeted against human immunodeficiency virus 1 (HIV-1) protease have resulted in effective antiviral therapies. However, the rapid replication of the virus and the inherent mutability of the viral genome result in the outgrowth of resistant strains in the major

Design and Synthesis of Pyrrolidine-5,5-

Design and Synthesis of Pyrrolidine-5,5- trans- lactams (5-Oxo-hexahydro-pyrrolo[3,2- b ]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl- trans -lactam Template

✍ Borthwick, Alan D.; Angier, S. Jane; Crame, Andrew J.; Exall, Anne M.; Haley, Te 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 183 KB

A Comparison of Cyclohexanone and Tetrah

A Comparison of Cyclohexanone and Tetrahydro-4H-thiopyran-4-one 1,1-Dioxide as Pharmacophores for the Design of Peptide-Based Inhibitors of the Serine Protease Plasmin.

✍ Fengtian Xue; Christopher T. Seto 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB 👁 1 views

A Comparison of Cyclohexanone and Tetrah

A Comparison of Cyclohexanone and Tetrahydro-4 H -thiopyran-4-one 1,1-Dioxide as Pharmacophores for the Design of Peptide-Based Inhibitors of the Serine Protease Plasmin

✍ Xue, Fengtian; Seto, Christopher T. 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 254 KB

Camptothecin-induced apoptosis in p53-nu

Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases

✍ Shimizu, T; Pommier, Y 📂 Article 📅 1997 🏛 Nature Publishing Group 🌐 English ⚖ 580 KB