In silico analysis of structural and functional consequences in p16INK4A by deleterious nsSNPs associated CDKN2A gene in malignant melanoma
β Scribed by R. Rajasekaran; C. George Priya Doss; C. Sudandiradoss; K. Ramanathan; Rao Sethumadhavan
- Book ID
- 116308947
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 675 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0300-9084
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Mutation analysis of two genes involved in melanoma susceptibility (CDKN2A/p16 INK4a and CDK4) was undertaken in 131 probands with a family history of melanoma. Screening of all three exons of CDKN2A and exon 2 of CDK4 by single-strand conformation polymorphism (SSCP) analysis and/or direct sequenci
Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16 INK4A (p16). Most benign tumours showed no p16 expression in the tumour