The p16 INK4A /CDKN2/MTS1 gene encodes a specific inhibitor of cyclin-dependent kinases (CDKs) 4 and 6. This study investigates p16 INK4A gene status and expression in mesenchymal tumours, in particular soft tissue sarcomas (STSs). Employing non-radioactive polymerase chain reaction-single strand co
β¦ LIBER β¦
Analysis of p16 (CDKN2/MTS-1/INK4A) gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy
β Scribed by G.D. Senner; N.C. Clements Jr.; J.A. Wymer; M. Aguirre; M.A. Nelson
- Book ID
- 114136717
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 125 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0165-4608
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## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w