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In search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-d-aspartate (NMDA) antagonists

✍ Scribed by Adam Bisaga; Piotr Popik


Book ID
117512774
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
194 KB
Volume
59
Category
Article
ISSN
0376-8716

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## Abstract Syntheses of a series of enantiomerically pure, substituted analogues 7b–t of SDZ EAB 515 (7a) were described (__Schemes 1__ and __2__). Affinites for the NMDA receptor were measured ([^3^H]CGP‐39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional t