The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differen
✦ LIBER ✦
In line with our ancestors: Oct-4 and the mammalian germ
✍ Scribed by Maurizio Pesce; Michael K. Gross; Hans R. Schöler
- Book ID
- 101304774
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 15 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The sentence at the bottom of the first column of p. 728 should read ''Oct-4 related genes exist in monotreme and marsupial species. . .'' not ''Oct-4 related genes exist in a monotreme marsupial species. . .''
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## Abstract The EWS‐Oct‐4 protein is a chimeric molecule in which the amino terminal domain (NTD) of the EWS becomes fused to the carboxy terminal domain (CTD) of the Oct‐4 transcription factor. It was identified in human bone and soft‐tissue tumors associated with t(6;22)(p21;q12). Using __in vitr