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In line with our ancestors: Oct-4 and the mammalian germ

✍ Scribed by Maurizio Pesce; Michael K. Gross; Hans R. Schöler

Book ID
101304731
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
347 KB
Volume
20
Category
Article
ISSN
0265-9247

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✦ Synopsis

The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation.

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