The antibody MAB007 was recently shown to be cysteinylated on an unpaired cysteine residue in the CDR3 variable region. Cysteinylation at this position was not complete and resulted in heterogeneous lots of MAB007 with respect to this posttranslational modification. In this report, a mild redox step
โฆ LIBER โฆ
Improving the Stability of an Antibody Variable Fragment by a Combination of Knowledge-based Approaches: Validation and Mechanisms
โ Scribed by Elodie Monsellier; Hugues Bedouelle
- Book ID
- 116663200
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 416 KB
- Volume
- 362
- Category
- Article
- ISSN
- 0022-2836
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