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Improving the radionuclidic purity of 94mTc for PET imaging

✍ Scribed by Bradley T. Christian; Robert J. Nickles; Charles K. Stone; Timothy L. Mulnix; John Clark

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 468 KB
Volume: 46
Category: Article
ISSN: 0969-8043
DOI: 10.1016/0969-8043(94)00130-r

No coin nor oath required. For personal study only.

✦ Synopsis

The production of 94mTC as pertechnetate, att/ 2 = 53 min positron emitter, was studied with small and medium energy cyclotrons. At a proton energy of 11 MeV, the irradiation of natural molybdenum provides adequate saturated yields (3 mCi/# A) with tolerable radionuclidic purity for radiopharmaceutical investigations in man. The longer lived 95Tc, 9SmTc and 96Tc isotopes can be virtually eliminated by irradiating an isotopically-enriched 94MOO3 target. In a study of alternative entrance channels leading to 94mTc, natural niobium and molybdenum targets were irradiated with 3He and 4He beams. The goal was to reach pure 94mTc through the 94Ru/94mTc generator system, bypassing contamination by the 94gTc ground state.

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