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Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

✍ Scribed by Abel Gonzalez-Perez, Jordi Deu-Pons, Nuria Lopez-Bigas


Book ID
120705367
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
294 KB
Volume
4
Category
Article
ISSN
1756-994X

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Single nucleotide polymorphisms (SNPs) are the simplest and most frequent form of human DNA variation, also valuable as genetic markers of disease susceptibility. The most investigated SNPs are missense mutations resulting in residue substitutions in the protein. Here we propose SNPs&GO, an accurate