Prognostic significance of p53 mutation
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Pierre O. Chappuis; Anne Estreicher; Barbara Dieterich; Hervé Bonnefoi; Michèle
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Article
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1999
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John Wiley and Sons
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French
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p53 status was tested in 180 patients with primary breast cancer using a yeast functional assay. Mutations were identified in 32% of cases. Only half were point missense mutations; the remainder were nonsense, insertion, deletion and splice site mutations. Twenty-two percent of mutations were locate