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Correlation of outcome of resected non-small-cell lung cancer (NSCLC) with p53 mutations detected by yeast functional assay

✍ Scribed by Monzó, M; O'Brate, A; Sánchez, J; Sancho, E; Rosas, I; Aracil, C; Guillot, M; Gutiérrez, J.J; Escobar, I; Astudillo, J; Rosell, R

Book ID
118570166
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
109 KB
Volume
29
Category
Article
ISSN
0169-5002

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✍ Pierre O. Chappuis; Anne Estreicher; Barbara Dieterich; Hervé Bonnefoi; Michèle 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 123 KB 👁 1 views

p53 status was tested in 180 patients with primary breast cancer using a yeast functional assay. Mutations were identified in 32% of cases. Only half were point missense mutations; the remainder were nonsense, insertion, deletion and splice site mutations. Twenty-two percent of mutations were locate