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Improving the Prediction of Complex Diseases by Testing for Multiple Disease-Susceptibility Genes

✍ Scribed by Quanhe Yang; Muin J. Khoury; Lorenzo Botto; J.M. Friedman; W. Dana Flanders


Book ID
117854150
Publisher
American Society of Human Genetics
Year
2003
Tongue
English
Weight
922 KB
Volume
72
Category
Article
ISSN
0002-9297

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For diseases with complex genetic etiology, more than one susceptibility gene may exist in a single chromosomal region. Under explicit assumptions about the number of disease genes in a region, generalized estimating equations (GEE) can be used to estimate the putative disease gene location(s) and e