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Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

✍ Scribed by Hugues Aschard; Jinbo Chen; Marilyn C. Cornelis; Lori B. Chibnik; Elizabeth W. Karlson; Peter Kraft

Book ID
113423249
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
28 KB
Volume
90
Category
Article
ISSN
0002-9297

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For complex diseases, the relationship between genotypes, environment factors, and phenotype is usually complex and nonlinear. Our understanding of the genetic architecture of diseases has considerably increased over the last years. However, both conceptually and methodologically, detecting gene-gen