Considerable advances have been made in identifying the factors determining the glycosylation pattern of glycoproteins secreted by mammalian cells. This has allowed a greater appreciation of the way in which recombinant proteins may be glycosylated after expression in a heterologous system. The stud
β¦ LIBER β¦
Improving protein glycosylation in mammalian cells with a glycosylation gene toolbox
β Scribed by Peiqing Zhang; Zhiwei Song
- Book ID
- 118472754
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 71 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0168-1656
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## Abstract Glycosylation has profound effects on the quality of recombinant proteins produced in mammalian cells. The biosynthetic pathways of Nβlinked glycans on glycoproteins involves a relatively small number of enzymes and nucleotide sugars. Many of these glycoconjugate enzymes can utilize mul
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