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Improving Liquid Chromatography-Mass Spectrometry Sensitivity Using a Subambient Pressure Ionization with Nanoelectrospray (SPIN) Interface

✍ Scribed by Keqi Tang; Jason S. Page; Ioan Marginean; Ryan T. Kelly; Richard D. Smith


Book ID
107700699
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
378 KB
Volume
22
Category
Article
ISSN
1044-0305

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A critical limitation of electrospray ionization (ESI) liquid chromatography/mass spectrometry (LC/MS) sources is the susceptibility to blockage of interface orifices due to the deposition of involatile components from the sample and/or mobile phase. These components, including salts, buffers, and i