Improvements in the production of [18F]N-methylspiroperidol and [18F]haloperidol
β Scribed by C.-Y. Shiue; J.S. Fowler; A.P. Wolf; C. Shea; M.J. Adam
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 99 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Syntheses of Nβ3(substituted) analogues of thymidine, Nβ3([^18^F]fluorobutyl)thymidine ([^18^F]βFBT) and Nβ3([^18^F]fluoropentyl)thymidine ([^18^F]βFPT) are reported. 1,4βButane diol and 1,5 pentane diol were converted to their tosyl derivatives **2** and **3** followed by conversion to
Fluorination with 18F-F2 and 18F-AcOF were compared for the synthesis of 18F-fluorophenylalanines. L-phenylalanine in CF,COOH trapped 18F-AcOF more effectively than 18F-F2. The main product was ortho-18F-fluorophenylalanine when 18F-AcOF was used as a reagent. Lower radiochemical yield of 18F-fluoro