Improvement of productivity of a Chinese hamster ovary cell by secretory pathway engineering
β Scribed by Takashi Takami; Akitoshi Nishizawa; Kohsuke Honda; Tomoshi Ohya; Takeshi Omasa; Hisao Ohtake
- Book ID
- 113682786
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 72 KB
- Volume
- 108
- Category
- Article
- ISSN
- 1389-1723
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## Abstract To improve the production of recombinant human antithrombin III (ATβIII) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBPβ1s (the spliced form of Xβbox binding protein 1), which were involved in the mammalia